Nicole M. Sifontis earned her Doctor of Pharmacy degree from the Philadelphia College of Pharmacy and Science in 1999 and completed an ASHP-accredited two-year Solid Organ Transplant Fellowship at the University of Illinois at Chicago.

In 2001, she joined the faculty at TUSP, where she established the first clinical pharmacy service for the kidney transplant program at Temple University Hospital. One of her most significant scholarly contributions, in collaboration with the National Transplant Registry, led to the FDA pregnancy category reclassification of mycophenolic acid, based on safety data from kidney transplant recipients. 

Since 2011, Dr. Sifontis has directed an advanced pharmacy practice global health medical mission experience that has prepared more than 100 pharmacy students to deliver care in underserved communities globally. In 2012, she co-developed an elective public health course that enabled students to apply knowledge to meaningful community service initiatives. One such initiative involved conducting patient home visits alongside community health workers, directly improving medication adherence and facilitating smoother transitions of care. In recognition of these contributions, she received the 2013 Elective Preceptor of the Year Award and the Outstanding Faculty Service Award. 

Dr. Sifontis's commitment to curricular innovation and responsiveness to diverse learning styles is reflected in the new courses she has developed, and the assessment strategies she has integrated into her teaching. In recognition of these efforts, she received the Golden Apple Award for Innovative Teaching in 2014, 2024, and 2025; and was honored with the Lindback Award for Distinguished Teaching in 2019.

In December 2025, Dr. Sifontis was named the Interim Chair, Pharmacy Practice, at TUSP.