Teaching & Academic Contributions
- PharmD Courses:
- Medicinal Chemistry III
- Graduate Teaching:
- Advanced Pharmacogenomics
Research Focus & Activities
Dr. Salim Merali specializes in proteomics, metabolomics, and drug discovery, particularly in diseases such as COPD, Alzheimer’s disease, metabolic disorders (e.g., insulin resistance, NASH), and infectious diseases. His lab integrates bioinformatics, translational medicine, and systems biology for therapeutic discovery.
Key Interests: proteomics and interomics in disease profiling; molecular targets for drug discovery (e.g., Nrf2, GLUT4, H3.3); translational regulation, nanoparticle delivery, and CRISPR-based screens; polyamine metabolism, inflammation, and fibrosis
Select Publications
- Merali C, Quinn C, Huffman KM, Pieper CF, Bogan JS, Barrero CA, Merali S. Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase. Obesity (Silver Spring). 2024 Dec;32(12):2286-2298.
- Yang Q, Langston JC, Prosniak R, Pettigrew S, Zhao H, Perez E, Edelmann H, Mansoor N, Merali C, Merali S, Marchetti N, Prabhakarpandian B, Kiani MF, Kilpatrick LE. Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity. Front Immunol. 2024 Mar 8;15:1341752.
- Quinn C, Rico MC, Merali C, Barrero CA, Perez-Leal O, Mischley V, Karanicolas J, Friedman SL, Merali S. Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction-associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells. Sci Transl Med. 2023 Sep 27;15(715):eade2966.
Leadership & Service Experience
- Director, Proteomics/Metabolomics, TUSP
- Associate Dean for Research, TUSP
- Founder, TamuroBio, Inc.
- Research Collaborator: Fox Chase Cancer Center, Penn State Cancer Institute, Yale, and Duke University
- Liaison, AACP