Teaching & Academic Contributions
- PharmD Teaching:
- Pharmacokinetics
- Graduate Teaching:
- Pharmacokinetics
- Principles of Pharmacokinetics
- Pharmacokinetic Principles in Drug Discovery and Development: Small and Large Molecules
- In Vitro-In Vivo Extrapolation in Pharmacokinetics
- Mechanism Based Pharmacokinetic-Pharmacodynamic Modeling
- Pharmacokinetic Principles to Meet Regulatory Guidance Requirements
- Pharmacokinetics and Mechanistic Modeling Certificate
- Advising: 2 doctoral student(s) (TUSP ); 10 postdoctoral fellow(s) (TUSP)
Research Focus & Activities
Dr. Nagar’s lab has a long-standing interest in understanding the disposition of conjugated metabolites, specifically the pharmacokinetics of metabolites with respect to their formation and transport. Her lab is currently conducting in vitro, preclinical, and bioanalytical assays to evaluate mechanisms of drug distribution kinetics. A second project in the lab focuses on intestinal absorption of orally administered drugs, and factors that can impact both absorption and enterohepatic recirculation of drugs. Further, in collaboration with Dr. Ken Korzekwa, she is developing methods to better understand complex kinetics of time-dependent enzyme inhibition. Another key collaborative area of research with the Korzekwa lab is developing models to predict intracellular concentrations in the presence of drug transporters.
Key Interests: small molecule pharmacokinetics; mathematical PK models; prediction of drug ADME in preclinical species and in humans.
Select Publications
- Nagar S, Parise R, Korzekwa K. Predicting Clearance with Simple and Permeability-Limited Physiologically Based Pharmacokinetic Frameworks: Comparison of Well-Stirred, Dispersion, and Parallel-Tube Liver Models. Drug Metab Dispos. 2024 Sep 16;52(10):1060-1072.
- Radice C, Korzekwa K, Nagar S. Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model. Drug Metab Dispos. 2022 Jun;50(6):750-761.
- Yadav J, Korzekwa K, Nagar S. Improved Predictions of Drug-Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A. Mol Pharm. 2018 May 7;15(5):1979-1995.
Leadership & Service Experience
- Associate Vice Provost, Graduate School, Temple University
- Associate Editor, Drug Metabolism
- Editorial Board, Drug Metabolism and Disposition, and Xenobiotica
- ISSX (International Society for the Study of Xenobiotics) Scientific Council
- Ad hoc Reviewer, NIH Study Sections