1. Teaching Contributions:
   1. PharmD Teaching: Medicinal Chemistry 1 (Biochemistry), Course coordinator, 4 credits)
   2. Graduate Teaching: Graduate courses: Principles of Biochemistry Course (Course coordinator, 4 credits), Advanced Drug and Gene Delivery Systems (Co-Course Coordinator, 3 credits), Introduction to Drug Design/Advanced Medicinal Chemistry (Team-taught, 3 credits) thesis/dissertation advising, mentorship: 4 PhD students: Shibbir Khan, Tashnuva Rifat, Lisa Petersohn, Mathias Sanchez
   3. Other Teaching Roles: Drug Delivery Certificate (Team-taught)
2. Research Overview:

Ilies lab interests lie in the broadly defined area of bio-organic & medicinal chemistry/chemical biology at membrane interfaces, where we combine heterocyclic chemistry and drug design, materials sciences and pharmaceutical sciences to generate novel therapeutic entities with a high therapeutic index.

Dr. Ilies authored over 85 publications, with > 4350 citations and an H index of 37. He is a member of the editorial board of four peer-reviewed journals on Biochemistry, Medicinal Chemistry and Advanced Drug and Gene Delivery Systems. Dr. Ilies chaired several sessions dedicated to the use of self-assembled systems in drug and nucleic acid delivery systems within the ACS Division of Colloid and Surface Chemistry. Besides ACS, he is an active member of AAPS, AACP, ASGCT and Rho Chi Honor Society. Dr. Ilies has a secondary appointment in the Alzheimer’s Center at Temple (LKSOM) and is a Collaborating Member of the Temple Fox Chase Cancer Center.

 Research Interests:

Up to 5 key areas of interest:

1. • Structure, function, inhibition and activation of metalloenzymes, aiming towards therapeutic applications
   • Synthesis, self-assembling, physicochemical and biological properties of assemblies of amphiphilic molecules of different molecular weights and packing parameters (surfactants, gemini surfactants, lipophilic oligomeric surfactants, lipids, dendrons, polymers)
   • Interfacial engineering of amphiphilic molecules for controlling the above-mentioned properties
   • Drug and gene delivery systems engineering, enzymatic degradation and toxicity
   • Nanoparticle synthesis, functionalization, loading, targeting, delivery, nanotechnology, for therapeutic purposes
2. Practice & Clinical/Community Engagement (If applicable):

NA

1. Key Publications:

S. Akocak, Md. R. Alam, A. M. Shabana, R. K. K. Sanku, D. Vullo, H. Thompson, E. R. Swenson, C. T. Supuran, M. A. Ilies “PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas”, J. Med. Chem., 59, 5077-88 (2016).

U. Satyal, B. Draghici, L. L. Dragic, Q. Zhang, K. W. Norris, M. Madesh, E. Brailoiu, M. A. Ilies “Interfacially-engineered pyridinium pseudo-gemini surfactants as versatile and efficient supramolecular delivery systems for DNA, siRNA and mRNA”, ACS Appl. Mater. Interfaces, 9 (35), 29481–29495 (2017).

A. M. Shabana, U. K. Mondal, Md. R. Alam, T. Spoon, C. A. Ross, M. Madesh, C. T. Supuran, M. A. Ilies, “pH-Sensitive Multi-ligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance”, ACS Appl. Mater. Interfaces, 10 (21), 17792–17808 (2018).

1. Administrative & Service Roles:
   1. Leadership roles: Committee Memberships: Academic Standing Committee; Admissions Committee, Merit Committee, Renzulli Scholars Committee, Curriculum Task Force).
   2. Institutional service: TUSP Senate Steering Committee Alternate Member
   3. Professional service:  Grant reviewer for different study sections and institutions within NIH, DoD, Foreign Science Institutions, International Foundations, International reviewer for different organizations; Ad-hoc reviewer for journals; organizer, chair for international, national and local conferences and symposia, Secretary and EC member of ACS Colloid and Surface Science Division; member of editorial boards of several professional journals, international and internal evaluator for several PhD candidates, book reviewer.
   4. Community outreach and advocacy initiatives: Secretary and EC member of ACS Colloid and Surface Science Division
2. Collaboration Interests & Opportunities:

All of our 5 main areas of research are open to joint research, student mentorship, and industry partnerships

1. Professional Profiles:

Links to Google Scholar: https://scholar.google.com/citations?user=wenG8lEAAAAJ&hl=en

Link to ResearchGate: https://www.researchgate.net/profile/Marc-Ilies

Link to LinkedIn: https://www.linkedin.com/in/marc-ilies-14771a2b/

ORCID: https://orcid.org/0000-0003-0694-411X

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