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Teaching & Academic Contributions

• PharmD Teaching: 
  • Medicinal Chemistry 

• Graduate Teaching
  • Principles of Biochemistry
  • Advanced Drug and Gene Delivery Systems
  • Introduction to Drug Design/Advanced Medicinal Chemistry
  • Drug Delivery Certificate
  • Advising: 4 doctoral students (TUSP)

Research Focus & Activities

Dr. Ilies’s lab interests lie in the broadly defined area of bio-organic & medicinal chemistry/chemical biology at membrane interfaces, where we combine heterocyclic chemistry and drug design, materials sciences and pharmaceutical sciences to generate novel therapeutic entities with a high therapeutic index. The group’s overall focus is on: (1) structure, function, inhibition and activation of metalloenzymes, aiming towards therapeutic applications; (2) synthesis, self-assembling, physicochemical and biological properties of assemblies of amphiphilic molecules of different molecular weights and packing parameters (surfactants, gemini surfactants, lipophilic oligomeric surfactants, lipids, dendrons, polymers); (3) interfacial engineering of amphiphilic molecules for controlling the above-mentioned properties; (4) drug and gene delivery systems engineering, enzymatic degradation and toxicity; and (5) nanoparticle synthesis, functionalization, loading, targeting, delivery, nanotechnology, for therapeutic purposes.

Dr. Ilies has authored over 85 publications and is a member of the editorial board of four peer-reviewed journals on Biochemistry, Medicinal Chemistry and Advanced Drug and Gene Delivery Systems. He has also chaired several sessions dedicated to the use of self-assembled systems in drug and nucleic acid delivery systems within the ACS Division of Colloid and Surface Chemistry. Outside of the ACS, he is an active member of AAPS, AACP, ASGCT and Rho Chi Honor Society. Dr. Ilies additionally has a secondary appointment in the Alzheimer’s Center at Temple (LKSOM) and is a Collaborating Member of the Temple Fox Chase Cancer Center.

Collaboration Opportunities:

Dr. Ilies is interested in collaborations regarding all five of his main areas of research, whether through joint research projects, student mentorships, or industry partnerships.

Key Interests: metalloenzymes and herapeutic applications; amphiphilic molecules; interfacial engineering; drug and gene delivery; nanoparticles/nanotechnology for therapeutic purposes

Select Publications

• Shabana AM, Mondal UK, Alam MR, Spoon T, Ross CA, Madesh M, Supuran CT, Ilies MA. pH-Sensitive Multiligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance. ACS Appl Mater Interfaces. 2018 May 30;10(21):17792-17808.
   
• Satyal U, Draghici B, Dragic LL, Zhang Q, Norris KW, Madesh M, Brailoiu E, Ilies MA. Interfacially Engineered Pyridinium Pseudogemini Surfactants as Versatile and Efficient Supramolecular Delivery Systems for DNA, siRNA, and mRNA. ACS Appl Mater Interfaces. 2017 Sep 6;9(35):29481-29495.
   
• Akocak S, Alam MR, Shabana AM, Sanku RK, Vullo D, Thompson H, Swenson ER, Supuran CT, Ilies MA. PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas. J Med Chem. 2016 May 26;59(10):5077-88.

Leadership & Service Experience

• • Academic Standing Committee, TUSP
  • Admissions Committee, TUSP
  • Merit Committee, TUSP
  • Renzulli Scholars Committee, TUSP
  • Curriculum Task Force, TUSP
  • Senate Steering Committee Alternate Member, TUSP
  • Grant Reviewer, NIH
  • Grant Reviewer, DoD
  • Secretary, ACS Colloid and Surface Science