Teaching & Academic Contributions
- PharmD Teaching:
- Pharmacokinetics
- Graduate Teaching:
- Advanced Pharmacokinetics
- Advanced Med Chem
- Pharmacokinetics and Mechanistic Modeling Certificates
- Advising: 1 doctoral student (TUSP)
Research Focus & Activities
Ken Korzekwa is a Professor of Pharmaceutical Sciences at Temple University School of Pharmacy. Ken received his B.S. in Chemical Engineering from New Mexico State University and his PhD in Medicinal Chemistry from the University of Washington. He received a PRAT Fellowship from the NIH and worked as a Staff Fellow and Senior Staff Fellow in drug metabolism and enzymology. He joined the University of Pittsburgh as an Associate Professor in the Department of Clinical Pharmacology and continued his research in drug metabolism. Predictive technologies developed by Ken and his colleague Jeff Jones were licensed to Camitro Corporation, a startup company in California. Ken joined Camitro as VP of Research in 1998. Ken then joined Merck as a Director/Distinguished Senior Investigator. After another start-up company, Ken joined TUSP in 2010 and teaches PharmD and graduate pharmacokinetics. Ken’s research in the areas of in vitro and in vivo drug metabolism, models for drug absorption, drug transport, time dependent inhibition, and human pharmacokinetic prediction.
Key Interests: mechanistic models for drug metabolism, absorption, distribution, and clearance; general human pharmacokinetic prediction
Select Publications
- Korzekwa K, Nagar S, Clark D, Sciascia T, Hawi A. A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate. Mol Pharm. 2024 Sep 2;21(9):4510-4523.
- Korzekwa K, Nagar S. Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts Are Correct. Drug Metab Dispos. 2023 Apr;51(4):532-542.
- Korzekwa K, Radice C, Nagar S. A permeability- and perfusion-based PBPK model for improved prediction of concentration-time profiles. Clin Transl Sci. 2022 Aug;15(8):2035-2052.