Teaching & Academic Contributions
- PharmD Courses:
- Pharmaceutics II
- Pharmacy Lab II
- Graduate Teaching:
- Advanced Drug ang Gene Delivery Systems
Research Focus & Activities
Dr. Ho-Lun Wong specializes in developing nanomedicine and targeted drug delivery, specifically, lipid-based and polymer/lipid hybrid nanosystems, to deliver small molecules, large molecules (e.g. RNA therapeutics and proteins) and their combinations for treatment of the diseases that are drug-resistant and/or poorly accessible by conventional drug therapy, with focus on the infectious diseases such as antibiotic-resistant bacteria and HIV. The key objective is to maximize delivery of drug to the desirable sites at desirable timing, so significantly enhanced efficacy and improved safety of treatment can become achievable.
Key Interests: Hybrid nanocarriers, lipid nanocarriers, targeted drug delivery, antibiotic-resistant bacterial diseases, HIV reservoir treatment
Select Publications
- Wu D, Si M, Xue HY, Tran NT, Khalili K, Kaminski R, Wong HL. Lipid nanocarrier targeting activated macrophages for antiretroviral therapy of HIV reservoir. Nanomedicine (Lond). 2023 Aug;18(20):1343-1360.
- Guo P, Si M, Wu D, Xue HY, Hu W, Wong HL. Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for treatment of HIV reservoir in brain. J Control Release. 2020 Dec 10;328:696-709.
- Guo P, Buttaro BA, Xue HY, Tran NT, Wong HL. Lipid-polymer hybrid nanoparticles carrying linezolid improve treatment of methicillin-resistant Staphylococcus aureus (MRSA) harbored inside bone cells and biofilms. Eur J Pharm Biopharm. 2020 Jun;151:189-198.
Leadership & Service Experience
- University Research and Creative Achievement Award Committee, Temple University
- Tenure and Promotion Committee, TUSP
- Research and Service Recognition Committee, TUSP
- Merit Committee, TUSP